Fat Loss
Peptides commonly researched in the context of body-fat reduction, appetite regulation, and metabolic remodeling.
Body-composition changes are highly individual. Most peptides in this category are either prescription-only or not approved for general use.
Semaglutide
Strong Human EvidenceA GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and chronic weight management (Wegovy).
Tirzepatide
Strong Human EvidenceA dual GIP/GLP-1 receptor agonist FDA-approved for type 2 diabetes (Mounjaro) and chronic weight management (Zepbound).
Retatrutide
Moderate Human EvidenceAn investigational triple GLP-1 / GIP / glucagon receptor agonist showing the largest weight-loss effects yet seen in mid-stage trials.
MOTS-c
ExperimentalA mitochondrial-encoded peptide studied for its role in metabolism, exercise capacity, and mitochondrial signaling.
Tesamorelin
Strong Human EvidenceA long-acting GHRH analog FDA-approved as Egrifta for HIV-associated visceral fat accumulation.
AOD-9604
Limited Human EvidenceA 16-amino-acid C-terminal fragment of human growth hormone studied for fat metabolism, with disappointing weight-loss outcomes in humans.
5-Amino-1MQ
Animal / LabA small-molecule NNMT inhibitor studied in obese mice for reducing fat mass and raising cellular NAD+ and SAM levels.
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