Semax
A Russian-developed ACTH(4-10) analog used intranasally and studied for cognitive performance and stroke recovery.
In plain English
Semax is a heptapeptide developed in Russia as a synthetic analog of the ACTH(4-10) fragment. It is administered intranasally and has been studied in Russian clinical practice for cognitive enhancement, stroke recovery, and optic-nerve disorders. The mainstream Western evidence base is small. People commonly research Semax for focus, attention, and post-stroke recovery. It is not FDA-approved.
What it is
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the ACTH(4-10) fragment, lacking the corticotropic activity of full-length ACTH.
Mechanism (summary)
Proposed mechanisms include modulation of BDNF and nerve growth factor, neuroprotective effects in ischemic injury, and influence on the dopaminergic system.
Why people research it
- Cognitive function and attention
- Ischemic stroke recovery
- Optic nerve injury
- ADHD-spectrum symptoms
Human evidence
Russian clinical trials describe benefits in acute stroke recovery and cognitive complaints. Mainstream English-language replication is limited.
Animal / lab evidence
Rodent studies show neuroprotective effects in ischemia models and modulation of growth factors and dopamine.
Key studies
Each summary explains the design, what was found, and what it doesn't prove.
In Russian stroke trials, Semax was linked to better neurological recovery scores than standard care alone.
A review of how Semax has been studied for memory and attention in animals and small human groups.
History
Developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Registered in Russia in 2000.
PeptidePedia is for educational and informational purposes only. We do not sell peptides, prescribe peptides, provide medical advice, or recommend treatment. Peptides may not be approved for human use except in specific legal prescription or clinical contexts. Always consult a licensed medical professional before making health decisions.